Allergic reactions to pollen and house dust, as well as food allergies are classified as type I allergies. Type I allergies develop when allergen-specific IgE antibodies are produced due to an excessive Th2-type immune responses. On the other hand, it is known that Th1-type immune responses suppress excessive Th2-type immune responses. It is expected that HK L-137 improves allergic symptoms, since HK L-137 enhances Th1-type immunity.
The effect of HK L-137 on the production of IgE was examined in a mouse allergy model. The administration of HK L-137 resulted in the suppression of IgE production, demonstrating the effect of HK L-137 on type I allergy.
Casein-containing diet was given to the mice that develop spontaneously food allergy against casein. Plasma anti-casein IgE titers were measured Weeks 2 and 4 after the intake of the casein diet. The mice were divided into two groups, either of which was given water containing 20 mg/L of HK L-137 from one week before the intake of the casein diet to the end of the study.
The increases in the plasma anti-casein IgE titers were significantly suppressed by HK L-137 intake.
HK L-137 enhances the Th1-type immune responses, which can suppress the Th2-type immune responses, thereby leading to suppression of IgE production. Over production of IgE antibodies, resulting from excessive Th2-type immune responses, is a major cause of type I allergy such as hay fever and food allergies.. Therefore, HK L-137 may be effective to prevent and alleviate allergies through the suppression of excessive Th2-type immune responses.
Reference: New Food Industry 51 (2). 10-16, 2009